U.S. Route 97 is a major north–south United States highway in the western United States. It begins at a junction with Interstate 5 at Weed, California, and travels north, ending in Okanogan County, Washington, at the Canadian Border, across from Osoyoos, British Columbia, becoming British Columbia Highway 97 upon entering Canada. Major cities that lie on US 97 include Klamath Falls, Oregon; Bend, Oregon; Yakima, Washington; Ellensburg, Washington; and Wenatchee, Washington. For a time, the Alaska portion of the Alaska Highway was planned to be signed as US 97, with signs even being produced.

A portion of the highway in California and Oregon is part of the Volcanic Legacy Scenic Byway.