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Schering-Plough
USINFO | 2013-08-02 10:42
| Schering-Plough Corporation | |
 |
|
| Former type | Subsidiary of Merck & Co. |
| Industry | Pharmaceuticals |
| Founded | 1971 (by merger with Plough, Inc.) |
| Defunct | 2009 |
| Headquarters | Kenilworth, New Jersey |
| Key people |
Fred Hassan Final CEO & Chairman |
Schering-Plough Corporation was aUnited States-based pharmaceutical company. It was founded in 1851 byErnst Christian Friedrich Schering asSchering AG in Germany. In 1971, the Schering Corporation merged with Plough (founded by Memphis area entrepreneur Abe Plough in 1908 [1]) to form Schering-Plough. On November 4, 2009 Merck & Co. merged with Schering-Plough with the new company taking the name of Merck & Co.
Schering-Plough manufactured several pharmaceutical drugs, the most well-known of which were the allergy drugs Claritin and Clarinex, an anti-cholesterol drug Vytorin, and a brain tumor drug Temodar. These are now available from Merck & Co.[2]
Schering Plough also owned and operated the major foot care brand name Dr. Scholl's and the skin care line Coppertone. These also became a part of the new company.[3]
As of June 2005, Schering-Plough had 1.4% market share in the U.S., placing it seventeenth in the top twenty pharmaceutical corporations by sales compiled by IMS Health.
Schering-Plough was a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA),[4] a membership which is also maintained by the new Merck.[5]
History
Pharmaceuticals and consumer products Schering was founded in 1851 by Ernst Christian Friedrich Schering asSchering AG in Germany.
Following the entry of the United States into World War II in 1941, U.S. President Franklin Delano Roosevelt ordered Schering AG's U.S. assets be seized. These became the Schering Corporation. The company was placed under a government administratorship until 1952, when it was released and its assets sold to the private sector.
In 1957, Schering acquired White Laboratories.[6]
Plough, Incorporated was founded by the Memphis, Tennessee area entrepreneur Abe Plough (1892–1984) in 1908 [1]. He borrowed $125 from his father to start the business at age sixteen. As a one man business, he mixed "Plough's Antiseptic Healing Oil," a "sure cure for any ill of man or beast," and sold it off a horse-drawn buggy.[1] He grew the company through sound management and innovative strategies, with marketing genius.
Plough's acquisitions included St Joseph's Aspirin for children,[1] Maybellinecosmetics, and Coppertone skin care products. Plough also had a broadcasting division, operating radio stations in Atlanta, Georgia; Baltimore, Maryland;Boston, Massachusetts; Chicago, Illinois; and Memphis, Tennessee.[7]
In 1971, the Schering Corporation merged with Plough, Inc. At the time of the merger, Abe Plough became Chairman of the combined company.[8]
In 2000, Schering Plough bought a new campus in Summit, New Jersey fromNovartis. The company planned to make this location its second-largest corporate complex in the world after completion of its current $20 million renovation.[citation needed]
Schering-Plough was named one of the 100 Best Companies for Working Mothersin 2004 and 2005 by Working Mothers magazine.
On March 9, 2009 it was announced that Schering-Plough and Merck were to merge. On November 4, 2009 Schering-Plough merged with Merck & Co. and through a reverse merger Merck became a subsidiary of Schering-Plough, which renamed itself Merck.[9][10][11][12]
Animal health
Coopers Animal Health
One of Schering-Plough's plants, in Upper Hutt, New Zealand was the largest single site for the production of veterinary vaccines in the world.This was primarily because New Zealand's isolation has formed a natural quarantine, leaving the country free of rabies, foot and mouth, scrapie, bovine spongiform encephalopathy, and many other livestock diseases. It formerly had echinococcosis, but this has been eradicated. The site was known locally as Coopers Animal Health, a trademark which was still in use by Schering-Plough in Australia, but not elsewhere.
Intervet
On 12 March 2007, Schering-Plough Corp. purchased Organon International, the drug unit of Netherlands-based Akzo Nobel, for $14.4 billion, giving the US pharmaceutical company an array of women's health products and numerous late-stage pipelines of experimental medicines.[13]
Organon itself was founded in 1923 by Dr. Saal van Zwanenberg, the president of Zwanenberg’sSlachterijen en Fabrieken. The company is housed at Zwanenberg’s premises in Oss, the Netherlands..[14] By August 21, 2008, Famvir (famciclovir) was marketed by Schering-Plough; formerly it was marketed by Novartis.As a result of the acquisition of OrganonBioSciences, Schering-Plough bolstered its animal health business with the Akzo Nobel subsidiary Intervet, obtained control of the active pharmaceutical ingredient manufacturer,Diosynth and gained access to human vaccine production through the subsidiary Nobilon. The three companies comprising OrganonBioSciences were--Organon, Diosynth, and Intervet.[13] HomeAgain continues to use the Intervet name owned by Merck.
Merck Animal Health, MSD Animal Health
After the merger of Schering-Plough with Merck the animal health division was still known as Intervet/Schering-Plough Animal Health.[15] A merger of Merial and Intervet/Schering-Plough was planned in 2010, but was abandoned in March 2011.[16] On June 29, 2011, the company announced that the animal health division would now be known as Merck Animal Health in the United States and Canada; it is now called MSD Animal Health elsewhere in the world.[17]
Chief executives
| Name | Tenure |
| Willibald H. Cozen | 1971 – 1979 |
| Richard J. Bennett | 1979 – January 31, 1982 |
| Robert P. Luciano | February 1, 1982 – December 31, 1995 |
| Richard J. Kogan | January 1, 1996 – April 2003 |
| Fred Hassan | April 2003 – November 3, 2009 |
Medical products
- Bridion (sugammadex)
- Cerazette
- Desloratadine - antihistamine branded Neoclarityn
- Esmeron/Zemuron (rocuronium)
- Famvir (Famciclovir) - for herpes zoster and shingles zoster treatment formerly Novartis
- Intron A & PEG-Intron Interferon alfa-2b - Hep C
- Levitra (vardenafil) - Erectile-dysfunction drug; co-marketed withBayer,and GlaxoSmithKline
- Livial (tibolone)
- Marvelon/Desogen
- Nasonex and Asmanex (Mometasonefuroate)
- Noxafil (posaconazole)
- NuvaRing
- Puregon/Follistim
- Quazepam (Doral)[18]
- Remeron/RemeronSolTab (mirtazapine)
- Remicade (infliximab)
- Suboxone (Buprenorphine/Naloxone)
- Temodar (temozolomide)
- Vytorin (ezetimibe/simvastatin) - Cholesterol-lowering combination drug
- Zetia (ezetimibe) - Cholesterol-lowering drug
- Afrin - A nasal spray decongestant
- Claritin (loratadine) - An antihistamine which has less risk of causingdrowsiness
- Coricidin - A palliative remedy for the common cold, targeted towards individuals with high blood pressure
- Coppertone - sunscreens
- Bain de Soleil - suncreen
- Drixoral
- Dr. Scholl's line of products
- Zinka - Colored sunscreen
Veterinary products
- Home Again Pet Recovery System - HomeAgain is an advanced pet identification and retrieval system.
- Zubrin - A non-steroidal anti-inflammatory drug (NSAID) for the treatment of osteoarthritis in dogs.[19]
- Mometamax - Is indicated for the treatment of canine acute externa andchronic otitis externa associated with yeast (Malasseziapachydermatis, formerly Pityrosporumcanis) and/or bacteria susceptible to gentamicin. It contains the strongest steroid (Mometasonefuroate) in Veterinary Medicine.[20]
- Eclipse Vaccines - Attenuated modified live feline vaccines available in a multitude of antigen combinations.[21]
- Galaxy Vaccines - Canine vaccines available in a multitude of antigencombinations.[22]
- Optimmune - Ophthalmic ointment (ciclosporin) for the treatment of Pannis and Keratoconjunctivitissicca in dogs.[23]
- Orbax - Trade name for orbifloxacin, a fluoroquinolone.[24]
- Otomax - Is indicated for the treatment of canine acute otitis externa andchronic otitis externa associated with yeast (Malasseziapachydermatis, formerly Pityrosporumcanis) and/or bacteria susceptible to gentamicin. It contains betamethasone valerate as an anti-inflammatory.[25]
- Banamine - A non-steroidal anti-inflammatory drug (NSAID) used in horses, cattle and swine in different parts of the world.[26]
- Estrumate - A synthetic prostaglandin used in reproduction of cattle.[27]
- Trivetrin - Trimethoprin sulfate for the treatment of cattle and swine.
- Nuflor-Florfenicol-for treatment of bovine respiratory disease, foot rot and control of respiratory disease in cattle at high risk of developing bovine respiratory disease.[28]
Exercise drug
Schering-Plough also received much publicity for a drug AICAR which mimics the effects of exercise, having especially potent effects when used alongside another drug GW1516 developed by GlaxoSmithKline.
Collaborative research
Controversy
In 2004, Schering-Plough was accused of marketing gimmicks and payoffs to doctors for prescribing the company's pharmaceutical products.[31]Schering-Plough entered into a Consent Decree with the FDA on March 6, 2002 due to manufacturing issues with its albuterol inhaler. It was ordered to pay $500 Million US dollars to the US Treasury.
