West Union Presbyterian Church (West Union United Presbyterian Church) is a historic church at 108 S. 2nd Street in West Union, Ohio. It is the oldest church building in Ohio that is still used as a church.
 
The church building was constructed in 1810 by Thomas Metcalfe, a mason who later became Governor of Kentucky. The church is nicknamed 'the "Church of the Governors," as Ohio's second governor, Thomas Kirker, helped organize the congregation and one of Kentucky's governors, Thomas Metcalfe, helped construct the church's walls.' The building was added to the National Register of Historic Places in 1976. The church is currently affiliated with the Presbyterian Church (U.S.A.).