The Ponce de Leon Inlet Light is a lighthouse and museum located at Ponce de León Inlet in Central Florida. At 175 feet (53 m) in height, it is the tallest lighthouse in the state and one of the tallest in the United States (the Cape Hatteras Light in North Carolina is taller at 207 feet). It is located between St. Augustine Light and Cape Canaveral Light. Restored by the Ponce de Leon Inlet Lighthouse Preservation Association, the lighthouse became a National Historic Landmark in 1998.

In 1982 the light was restored to active service, primarily because highrise buildings blocked the Coast Guard's beacon on the other side of the inlet. The Ponce De Leon Inlet Light Station was designated a National Historic Landmark on August 5, 1998, one of only ten lighthouses to earn this designation.

The lighthouse and three keepers' dwellings have been restored, and are open to the public seven days a week. The lighthouse tower is open for climbing. The original 1867 Barbier et Fenestre first order fixed lens (installed 1887), and 1860 "Henry Lepaute" rotating first order Fresnel lens used at Cape Canaveral Light Station are all on display at the museum. The 1904 Barbier Benard et Turenne rotating third order Fresnel lens has been restored to service in the tower, which operates today as a private aid to navigation and is maintained by the museum staff. It is just south of Daytona beach.

There were many shipwrecks along the coast near the Mosquito Inlet, but it was not until 1883 that another effort was made to place a light there. The new lighthouse was based on Light-House Board standard plans with modifications made for the specific site.

Construction was supervised by Chief Engineer Orville E. Babcock until his death by drowning in the Mosquito Inlet in 1884. The tower was completed and the lamp, which could be seen twenty miles (32 km) away, lit in 1887.

In 1927 the name of Mosquito Inlet was changed to Ponce de Leon Inlet. The lighthouse was transferred from the abolished Lighthouse Service to the Coast Guard in 1939, which would oversee it for the next three decades. In 1970, the Coast Guard abandoned the old light station and established a new beacon at New Smyrna Beach. The abandoned property was then deeded to the Town of Ponce Inlet. At the urging of concerned citizens, the Town of Ponce Inlet accepted the Light Station property from the Coast Guard in 1972, and the Lighthouse Preservation Association was formed to manage the museum. That same year, the lighthouse was listed on the National Register of Historic Places.