Today
The original focus of the label was on hip-hop and urban music, but by the mid 1990s its range began to expand, to where its roster would be as wide ranging to include the industrial rock artist Nine Inch Nails under Nothing Records, shock rocker Marilyn Manson, rock band Limp Bizkit, Helmet, No Doubt and later the Latin artist Kings Of Flow in a unique partnership with Los Angeles based indie Latin label.

Following UMG's acquisition of PolyGram in 1998, Geffen Records and A&M Records were merged into Interscope. In 2004, DreamWorks Records was merged into the Interscope-Geffen-A&M group bringing over artists including Blink-182, Papa Roach, Rise Against, Nelly Furtado, Lifehouse, AFI, The All-American Rejects, Jimmy Eat World and Rufus Wainwright. The artists were divided between Interscope and Geffen, with most going to the latter. In 2005 Interscope launched a new imprint called Cherrytree Records, for emerging artists. This began with the group The Lovemakers and later included Far East Movement, Feist, Natalia Kills, Flipsyde, Tokio Hotel, and Robyn. Lady Gaga is with Interscope, but no longer with Cherrytree as of 2011. LMFAO and Mindless Behavior are also part of the Interscope Records Major Hits.

In May 2007 Interscope announced a joint-venture partnership with Justin Timberlake to create a new recording label called Tennman Records, with the first artist being Esmee Denters.

In 2011, Interscope signed Madonna and Van Halen, the latter of which reunited with its original lead singer David Lee Roth. Both artists' albums were released in 2012. Also in the same year, Interscope signed Girls' Generation, a girl group from South Korea.

Current Artists
50 Cent (Shady/Aftermath/Interscope) 

Ab-Soul (Top Dawg Entertainment/Interscope)
Lauren Alaina (19/Interscope/Mercury Nashville)
Alex_242 (Rowdy/Interscope)
The All-American Rejects (Doghouse/DGC/Interscope) 

Bad Meets Evil (Shady/Interscope)
Azealia Banks
The Black Eyed Peas (will.i.am/Interscope)
Aloe Blacc

Colette Carr (Cherrytree/Interscope)
Cassie (Bad Boy/Interscope)
Chief Keef (Glory Boyz/Interscope)
Priyanka Chopra 

Ester Dean (Zone 4/Interscope)
Lana Del Rey (Interscope/Stranger)
The Diplomats
Disco Curtis (MySpace/Interscope)
Dr. Dre (Aftermath/Interscope) 

Eminem (Shady/Aftermath/Interscope)

Far East Movement (Cherrytree/Interscope)
Feist (Cherrytree/Interscope)
Fergie (will.i.am/Interscope)
Frank + Derol
Frankmusik (Cherrytree/Interscope)
French Montana (Bad Boy/Interscope)
Nelly Furtado (Mosley/Interscope) 

Game (The Black Wall Street/Interscope)
Girls' Generation (S.M. Entertainment USA/Interscope)
Ellie Goulding (Cherrytree/Interscope)
Skylar Grey (Wonderland/Interscope) 

Keri Hilson (Zone 4/Mosley/Interscope)
Hit-Boy

Imagine Dragons (KIDinaKORNER/Interscope) 

Jamie N Commons
Carly Rae Jepsen (Schoolboy/Interscope) 

Natalia Kills (will.i.am/Cherrytree/Kon Live/Interscope)
Michael Kiwanuka (Cherrytree/Interscope)
Matthew Koma (Cherrytree/Interscope)

La Roux (Cherrytree/Interscope)
Lady Gaga (Streamline/Kon Live/Interscope)
L.E.P. Bogus Boys (Infared/Interscope)
Kendrick Lamar (Top Dawg Entertainment/Aftermath/Interscope)
Lawson
LMFAO (will.i.am/Cherrytree/Interscope)
Los
Pixie Lott 

M.I.A. (N.E.E.T./Interscope)
Madonna (Live Nation Worldwide/Interscope)
Mateo (Krucial Noise/Interscope)
Scotty McCreery (19/Interscope/Mercury Nashville)
MGK
Midnight Red
Mindless Behavior (Streamline/Interscope)
Modestep
Willy Moon (Cherrytree/Interscope) 

Nero (Cherrytree/Interscope)
Megan Nicole (Bad Boy/Interscope)
Nick Gardner
No Doubt

OMG Girlz
One More Girl
OneRepublic (Mosley/Interscope) 

Phillip Phillips (19/Interscope)
The Pretty Reckless 

Schoolboy Q (Top Dawg Entertainment/Interscope)

Red Café
Rise Against (DGC/Interscope)
Robyn (Konichiwa/Cherrytree/Interscope)
Jay Rock (Strange Music/Top Dawg Entertainment/Interscope)
The Rolling Stones (ABKCO/Interscope)
Rye Rye (N.E.E.T./Interscope) 

Jessica Sanchez
Nicole Scherzinger
Eva Simons
Brit Smith
Slaughterhouse (Shady/Interscope)
Starshell
Gwen Stefani
Sting (Cherrytree/Interscope) 

Robin Thicke (Star Trak/Interscope)
Timbaland (Blackground/Mosley/Interscope)
Tokio Hotel (Cherrytree/Interscope)
Frank Turner (Xtra Mile/Interscope)

U2 

Van Halen 

Jessie Ware (Cherrytree/Interscope)
will.i.am (will.i.am/Interscope)
Woodkid

Yeah Yeah Yeahs (DGC/Interscope)
Yelawolf (Ghet-O-Vision/DGC/Shady/Interscope) 

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