U.S. Route 17 or U.S. Highway 17 (abbreviation U.S. 17, US 17, also known as the Coastal Highway) is a north–south United States highway. The highway spans the southeastern United States and is close to the Atlantic Coast for much of its length. The highway's southern terminus is at Punta Gorda, Florida, at an intersection with U.S. Route 41. Traveling north, US 17 joins up with US 50 in Paris, Virginia, and the northern terminus of US 17 is in downtown Winchester, Virginia. This is also the point at which the portion of US 50 called the Northwestern Turnpike begins.

Though U.S. Route 1 is generally considered to be the highway that runs alongside Interstate 95, US 17 runs parallel to I-95 for much of its extent, and even shares the same route for short spans in Fredericksburg and Ridgeland.