U.S. Route 60 is an east–west United States highway, running 2,670 mi (4,300 km) from the Atlantic Ocean on the east coast in Virginia to western Arizona. Despite the final "0" in its number, indicating a transcontinental designation, the 1926 route formerly ended in Springfield, Missouri, at its intersection with the major U.S. Route 66. In fact, Route 66 was almost given the US Route 60 number.

As of 2005, the highway's eastern terminus is in Virginia Beach, Virginia, at Atlantic Avenue in the city's oceanfront resort district at the Rudee Inlet Bridge, right at the Grommet Island Park. Its western terminus was in Los Angeles, California, from 1932 to 1966, but that was moved to east of Quartzsite, Arizona, to an intersection with Interstate 10 after the highway designation was removed in California in 1964. Some US 60 signs can be seen at this intersection about 5 mi (8.0 km) west of Brenda, Arizona. Interstate 10 replaced US 60 from Arizona to Beaumont, California, and California State Highway 60 replaced US 60 from there to Los Angeles.