U.S. Route 62 runs from the US-Mexico border at El Paso, Texas to Niagara Falls, New York, near the United States-Canada border. It is the only east-west US Route that connects Mexico and Canada.

Parts of U.S. 62 follow what once was the Ozark Trail, including the historic bridge across the South Canadian River in Newcastle, Oklahoma[3] (the first structure built with federal highway funds in Oklahoma).