U.S. Route 63 (US 63) is a 1,286-mile (2,070 km) long north–south United States highway primarily in the Midwestern United States. The southern terminus of the route is at Interstate 20 in Ruston, Louisiana. The northern terminus is at U.S. Route 2 in Benoit, Wisconsin, about 60 miles (97 km) east of Duluth, Minnesota. It is not related to U.S. Route 163, which is located near the Four Corners Monument in the southwestern United States.