U.S. Route 64 is an east–west United States highway that runs for 2,326 miles (3,743 km) from eastern North Carolina to just southwest of the Four Corners in northeast Arizona. The western terminus is at U.S. Route 160 in Teec Nos Pos, Arizona. The highway's eastern terminus is at NC 12 and U.S. Route 158 in Nags Head, North Carolina.