The Merchants' Exchange Building is an historic building located on the triangular site bounded by Dock Street, Third Street, and Walnut Streetin the Old City neighborhood of Philadelphia, Pennsylvania. It was built between 1832 and 1834, and was designed by architect William Strickland, in the Greek Revival style, the first national American architectural style. It operated as a brokerage house in the nineteenth century, but by 1875 thePhiladelphia Stock Exchange had taken the place of the Merchants' Exchange.

The building was declared a National Historic Landmark in 2001. It is the oldest existing stock exchange building in the United States, but is now used as the headquarters of the Independence National Historical Park.