Rancho Los Amigos National Rehabilitation Center is a rehabilitation hospital located in Downey, California, United States. Its name in Spanish means "Friends' Ranch". It is accredited by the Joint Commission (JC) and the Commission on Accreditation of Rehabilitation Facilities (CARF). Out of 4,852 facilities analyzed for the 2010-11 Best Hospitals rankings, only 152 were ranked in any of the 16 specialties. Rancho Los Amigos is included in the "Best Hospital" rankings.

Rancho Los Amigos National Rehabilitation Center is one of the largest comprehensive medical rehabilitation centers in the U.S. providing services to a wide range of individuals with catastrophic illnesses and injuries.
Rancho specializes in helping patients with disabilities regain skills and learn techniques to accomplish the basic activities of daily living, and returning to work or school if possible.
For more than two decades, Rancho has been ranked among "America's Best Hospitals" in Rehabilitation Medicine by U.S.News & World Report. In 2011, U.S.News ranked the Downey, California-based hospital 7th among the 138 hospitals rated in the Greater Los Angeles area.
Rancho is licensed for 207 beds. It cares for approximately 4,000 inpatients and conducts 78,000 outpatient visits annually. The hospital provides rehabilitation services in stroke, spinal cord injury, brain injury, pediatrics, orthopedics and diabetes care, pressure ulcer management, limb preservation and post- amputation care. These services help patients to obtain as much independence as they are able, so they may return to their family, school or a job if feasible.