Charles Gwathmey (June 19, 1938 – August 3, 2009) was an American architect. He was a principal at Gwathmey Siegel & Associates Architects, as well as one of the five architects identified as The New York Five in 1969. One of Gwathmey's most famous designs is the 1992 renovation of Frank Lloyd Wright's Guggenheim Museum in New York City.

Born in Charlotte, North Carolina, he was the son of the American painter Robert Gwathmey and photographer Rosalie Gwathmey. Charles Gwathmey attended the University of Pennsylvania and received his Master of Architecture degree in 1962 from Yale School of Architecture,  where he won both The William Wirt Winchester Fellowship as the outstanding graduate and a Fulbright Grant.

Gwathmey served as President of the Board of Trustees for The Institute for Architecture and Urban Studies and was elected a Fellow of the American Institute of Architects in 1981.

Career
From 1965 through 1991, Gwathmey taught at Pratt Institute, Cooper Union for the Advancement of Science and Art, Princeton University, Columbia University, the University of Pennsylvania, the University of Texas, and the University of California at Los Angeles. He was Davenport Professor (1983 and 1999) and Bishop Professor (1991) at Yale, and the Eliot Noyes Visiting Professor at Harvard University (1985). Gwathmey was the Spring 2005 William A. Bernoudy Resident in Architecture at the American Academy in Rome.

Gwathmey's firm designed the Museum Of Contemporary Art of North Miami, Florida in 1995, and the Astor Place Tower, a 21-story condominium project in Manhattan's East Village, in 2005. In 2011 the Ron Brown Building the new home of the United States Mission to the United Nations for which he was the lead architect was dedicated. Ambassador Susan Rice in her remarks thanked Gwathmey posthumously.

Gwathmey died of esophageal cancer on August 3, 2009. He was 71.

Awards and honors
Gwathmey was the recipient of the Brunner Prize from the American Academy of Arts and Letters in 1970, and in 1976 he was elected to the Academy. In 1983, he won the Medal of Honor from the New York Chapter of the American Institute of Architects and in 1985, he received the first Yale Alumni Arts Award from the Yale School of Architecture. In 1988 the Guild Hall Academy of Arts awarded Gwathmey its Lifetime Achievement Medal in Visual Arts, followed in 1990 by a Lifetime Achievement Award from the New York State Society of Architects.