SignatureSchool is a top-ranked charter high school located in downtown Evansville, Indiana, on the Main Street walkway. The school opened in 2002 as Indiana's first public charter high school. It attracts top tier students and is consistently ranked as one of the top high schools in the United States.

Signature School began in 1992 as a half-day program with 213 students. It offered both morning and afternoon classes for motivated high school students who wanted to be challenged and take higher level courses. The ACE program (The Accelerated, Compacted, Enriched Program) was developed for freshmen and sophomores wanting more advanced English, foreign language, math, and science courses.

By 2001, Signature School had 278 part time students. After the passage of the Indiana Charter School Law, the staff at the time saw an opportunity to apply for a full-day program, adopt more courses into its curriculum, and become a charter school. In December 2001, Signature School submitted a charter-seeking conversion status to the Evansville Vanderburgh School Corporation (EVSC) and on February 25, 2002, the EVSC approved the charter. At the time it was Indiana's first public charter high school.

The first graduation ceremony for Signature School students was held in May 2003 in the Victory Theatre. There were 42 students in that first graduating class.

The Signature School is located in several buildings in downtown Evansville, Indiana, on the Main Street walkway. These include the fourth floor of the Victory theater; the Robert L Koch II Science Building, which is attached to The Gerling Law Firm offices, the YMCA for PE classes, and the Browning Rooms at Central Library. The school's main building is attached to the historicVictory Theater. The building now known as Signature School was originally a hotel, and was gutted and remodeled to be a school. Because of the building's history as a hotel, many of the classrooms are renovated hotel rooms and remain small in size, and also due to this past as a hotel, the floors are small and there are many of them.

Unlike other high schools, Signature students do not eat in a school cafeteria, but at one of the numerous restaurants located in downtown Evansville. Students who bring their lunches may also elect to eat across the street from the school in a room called the Commons in the 2nd floor of the Signature School Science Center. Students sign up each morning for a restaurant, the Commons, the Grassy Knoll, or a classroom and sign in with a teacher assigned to that restaurant.