La Reina High School is a private Catholic college preparatory junior and senior high school for girls sponsored by the Congregation of the Sisters of Notre Dame, founded in 1850 in Coesfeld, Germany. The Christian education of youth has always been the Congregation's principal apostolic activity. The integration of the instruction in Catholic truths and values with human knowledge in all aspects of the school program has as its purpose the formation of mature, Christian young women. Therefore, both the religious and lay faculty at La Reina High School endeavor to educate each student in such a way that she may reach her fullest spiritual and intellectual potential in an atmosphere of loving concern and religious commitment where quality and the individual count.

La Reina was established in the fall of 1964. The school campus is situated on a 40-acre parcel of land. The three original buildings were completed between 1964-1967. His Eminence James Francis Cardinal McIntyre dedicated La Reina on October 15, 1967. The multi-purpose building, consisting of an auditorium-gym, cafeteria, five classrooms, a computer lab and nine offices was built in 1986. This building completed the campus, increasing the maximum enrollment from 400 to approximately 620.