In 1950, seven small school districts in Arapahoe County were consolidated to form Cherry Creek School District No. 5, eliminating original School District #19 and making its one-room schoolhouse obsolete. In 1953 the schoolhouse was sold at public auction; and for the next 16 years, it was used as a storage shed. The consolidation brought the eight schools of Ash Grove, Castlewood, Cherry Creek, Cherry Hills (Cherry Creek), Cunningham, Maple Grove, Mountain View, and Sullivan (Mountain View) together for educating elementary students, but Cherry Creek area high school students did not have their own school until 1955. Appropriately, it was named Cherry Creek High School. On September 6, 1955, the school opened its doors to 364 high school students (grades 9-12) and an additional 349 younger students (grades 7-8) who had to wait until the following year for their own Cherry Creek Junior High School building to be completed.

The district bought land at the corner of South Holly Street and East Belleview Avenue in 1965, and built a second junior high school, Cherry Creek West Junior High, which opened its doors in September 1966 to 655 students, although construction was not complete until that November (for example, there was no cafeteria until then). When Cherry Creek West Junior High was opened, both it and the original junior high, renamed Cherry Creek East Junior High (now known as Campus Middle School), housed grades 7-9, making the high school a three year high school (grades 10-12).

Four separate additions were made to the high school building before 1970, more than doubling its size. The Vocational-Practical Arts Center (1970), and the Performing Fine Arts Center (1974) were added to the campus unit between the West Building, which was the entire Cherry Creek High School in 1955, and the East Building. The latter reverted to the high school when Campus Middle School was built in 1971 (grades 7-8), and Cherry Creek became again a four-year high school. Additional major renovations occurred in 1997 when the Vocational Industrial Arts Building was transformed into the Information Center. Additions to East, Fine Arts, and West were completed in 2005.

The original $800 one-room Cherry Creek Schoolhouse, found on a ranch north of Parker, was purchased and brought back to the high school campus in 1969. Restored and now serving as a museum-classroom, it rests south of the Information Center building.