Upper Kirby is a commercial district in Houston, Texas, United States.

Upper Kirby contains many businesses, including restaurants. Upper Kirby is east of the Greenway Plaza, southwest of Neartown, north of the city of West University Place, and south of River Oaks.

Upper Kirby is considered to be in an area west of South Shepherd Drive, east of Buffalo Speedway, north of Bissonnet Street, and south of Westheimer Road.

The River Oaks Garden Club Forum of Civics, located in Upper Kirby, is listed in the National Register of Historic Places as the "Forum of Civics" on October 13, 1988. Formerly a county schoolhouse, the building is currently the administrative center for the River Oaks Garden Club.

The Texas Department of Criminal Justice (TDCJ) operates the Houston II Parole Office in Upper Kirby. At one time the Texas Youth Commission Houston District Office was located in Upper Kirby.